

✨ Glow smarter, age slower with every drop!
This 1 fl oz Nitric Oxide Activating Serum combines a potent 20% Vitamin C antioxidant complex with Nitric Oxide to hydrate, brighten, and smooth skin. Clinically designed to reduce wrinkles, minimize pores, and fade dark spots, it supports collagen production and improves skin texture without harsh chemicals. Suitable for all skin types, it offers up to 70 easy daily applications, making it a must-have for millennials seeking radiant, youthful skin with a science-backed edge.

















| ASIN | B08LNTJZST |
| Best Sellers Rank | #37,020 in Beauty & Personal Care ( See Top 100 in Beauty & Personal Care ) #825 in Facial Serums |
| Customer Reviews | 4.1 4.1 out of 5 stars (297) |
| Item model number | n1o1 |
| Manufacturer | Pneuma Nitric Oxide |
| Product Dimensions | 6 x 2 x 2 inches; 11.99 ounces |
| UPC | 608597658903 |
F**R
Removed my scar, despite infrequent use
Three years ago, I cut my face right in between my eyebrows. I got left with a 1/4” scar that ran deep, extended my wrinkle and gave me a permanently worried look. It got worse over time. My trusty moisturizer helped everywhere, except for the scar. The need to do something overcame my skepticism about nitric oxide, so I decided to give it a chance. I had no expectations. The instructions recommend daily application. I applied about twice a week. For a couple weeks, there was no change. Maybe a month later I noticed the scar is no longer joined to my eyebrow wrinkle, reducing my angry, worried look. I began applying every other day and after a few more weeks, the scar is now flat and only visible within a few feet distance. By flat I mean no longer deep, almost completely flush with the skin, with a very slightly discolored center. The scar basically shrank in size and almost disappeared optically. My wrinkles also improved substantially. I now believe that the scar will disappear completely with another few weeks of frequent use. I started to apply all over my face and neck, since the minimum dose is large enough. I’m now administering to whoever asks: seniors, youth, children, … whoever has skin damage. The cream itself clogs pores a little so I shower it off at the end of the day. It’s not suitable for wearing light colors as it can stain them yellow. I wish it came in glass instead of plastic. I thought I’d keep my scar for the rest of my life, looking progressively angrier as I age. And yet, here we are - I’ve reversed three years of skin damage. Thank you Dr. Nathan Bryer!
D**.
It works!
This is my no. 1 go-to serum. I have been using it since 2021 and have seen a great improvement in the smoothness of my skin, particularly around my eyes. One morning in 2021, I looked in the mirror and it was like somebody pulled a switch. The delicate skin around the eyes, that had been fairly smooth, suddenly sagged and looked baggy. None of my existing products did anything. Fortunately, I saw a TV commercial for the N1O1 serum and decided to give it a try. Since I am a woman of a certain age, I followed the instructions and began using it twice a day, with emphasis on the eye area. I have sensitive skin around the eyes and on the cheeks. There was, and still is, no irritation. Within about 3 days, there was improvement. The skin looked much more lifted. The whole eye area began to smooth out. In fact, since I was applying the serum over my whole face, my facial skin began to look smoother. Pores looked smaller, and the skin tone was more even. The effect of the serum seems to build over time. I continue to use the serum every day and am very pleased with the results.
J**W
One dispenser was inoperable
I was very excited to use the serum as I have had great results with their eye cream. The unit is packaged as two separate products in one bottle. So there are two dispensers and the instructions state to dispense one pump from each dispenser and mix them both together to activate the serum. One dispenser worked fine, the other one didn't dispense anything. The pump worked, but nothing came out. Amazon was great about the return and I really wanted a replacement because I did want to try the serum but at just under $200 for a small bottle I didn't want to take a chance on this packaging defect being an issue again.
D**I
As advertised
I have been using this product for a couple days. It is important to know that a little bit goes a long way with this serum, I can easily cover my whole face with about half a lump from each side. Also, I had no problems with the pumps like other people have experienced. Besides the price, I like it a lot! I am using mainly on my face currently and I can tell my skin is liking it so far. The vitamin C in the serum does leave a little bit of an orange hue like the back label warns about but it honestly looks more like I have an even and glowing tan. I got this product to help with pores and under eye puffiness. I currently see it is already starting to help with pores and hope it will do the same for the eye puffiness. Thank you for the quality product!
S**E
The Jury is Out
I just finished my first bottle. The good news, using it religiously twice a day, one full pump each side, the bottle lasted just over 6 weeks, so a bit more than the advertised 70 applications. At this point, I see moderate improvement in skin brightness and clarity. The product isn’t moisturizing on me, but it isn’t drying either. I see no improvement in dark circles, fine lines or sun/age spots. I purchased my first bottle on a promo at $58. The serum is now up to $77 with a coupon, $120 retail. I am willing to give it another 6 weeks, but without additional improvements, I will not continue spending the $$ on this serum. UPDATE: I used the serum for 6 months. Five Stars for making my complexion bright and clear, eliminating minor red blotching and evening out skin tone. I think my skin looked great. As for fine line reduction, I didn't notice any difference. I stopped using the serum about a month ago and notice that my complexion is slipping back to its previous state. I am on the fence about repurchasing the product. The bottle contains about a 45 day supply, but at the new even higher price, I'm still on the fence about the investment for a nice but not particularly significant outcome.
B**Y
Best face serum I've ever used!
LOVE the combination of this serum! It tightened my face and helped keep my face looking its best. I truly loved it and it's worth every penny! I am 45+ and have become very purposeful with every serum and face cream I use these days. This was never oily, it never broke out my skin, and the results have been obvious! Thrilled with the results.
A**A
Feels good to use as a moisturiser - haven't seen any measurable improvements.
B**E
Good design but outrageous price
Trustpilot
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3 weeks ago