Alpha-Lipoic Acid by Dr. Danielle, Neuropathy Support, Non-GMO, Gluten-Free, Vegan, Soy-Free, Promotes Healthy Blood Sugar, Alpha R Lipoic Acid R-ALA, R-ALA, 120 Veggie Caps

If you read the information I posted below, you will understand why only R-ALA makes sense to take and on an empty stomach. I like this product because it is R-ALA, and the price is reasonable for the dosage of 300mg and the number of capsules. I also like Doctors Best Stabilized R-Lipoic acid, which claims to Feature BioEnhanced™ Na-RALA, a more bioavailable form. Not sure I notice a difference, but it is more expensive, with lower dose and fewer capsules which is why I switched to this one. My favorite ALA product is not sold to the public but through practitioners (doctors, naturopaths, accupuncturists, chropractors) Researched Nutritionals C-RLA Liposomal Vitamin C and R-Lipoic Acid and is very expensive $100 for ten fluid ounces. The dosage is much lower -- two teaspoons with 70 mg's RLA but I feel it immediately. This is the product Dr. Horowitz, the famous Lyme disease physician gives to his patients to stimulate glutathione synthesis and help clear toxins from the infection. If you are new to alpha lipoic acid I suggest you read the material on from the Linus Pauling Institute: http://lpi.oregonstate.edu/infocenter/othernuts/la/ Summary: Only the R- isomer is endogenously synthesized and bound to protein: R-LA occurs natural in foods. LA supplements may contain either R-LA or a 50/50 (racemic) mixture of R-LA and S-LA. Dietary and Supplemental Alpha-Lipoic Acid Exogenous LA from the diet can be activated with ATP or GTP by lipoate-activating enzyme, and transferred to LA-dependent enzymes by lipoyltransferase (10, 11). Consumption of LA from food has not yet been found to result in detectable increases of free LA in human plasma or cells (3, 12). In contrast, high oral doses of free LA (≥ 50 mg) result in significant but transient increases in free LA in plasma and cells. Pharmacokinetic studies in humans have found that about 30%-40% of an oral dose of LA (a 50/50 mixture of R-LA and S-LA) is absorbed (12, 13). Oral LA supplements are better absorbed on an empty stomach than with food: taking LA with food decreased peak plasma LA concentrations by about 30% and total plasma LA concentrations by about 20% compared to fasting (14). Additionally, the sodium salt of R-LA may be better absorbed than free LA, presumably because of its higher aqueous solubility (15). There may also be differences in bioavailability of the two isomers of LA. After oral dosing with LA, peak plasma concentrations of R-LA were found to be 40%-50% higher than S-LA, suggesting that R-LA is better absorbed than S-LA (12, 14, 16). Following oral administration, both isomers are rapidly metabolized and excreted. Plasma LA concentrations generally peak in one hour or less and decline rapidly (12, 13, 16, 17). In cells, LA is quickly reduced to DHLA, and studies in vitro studies indicate that DHLA is rapidly exported from cells (3). Although LA is a potent antioxidant in the test tube, LA supplementation may affect health by stimulating glutathione synthesis, enhancing insulin signaling, and modulating the activity of other cell-signaling molecules and transcription factors. (More information) Overall, the available research indicates that treatment with 600 mg/day of intravenous LA for three weeks significantly reduces the symptoms of diabetic peripheral neuropathy. (More information) Compared with intravenous administration, the effect of long-term, oral LA supplementation for diabetic peripheral neuropathy is less clear, yet some studies show that oral supplementation with at least 600 mg/day of LA may be beneficial. (More information) If you choose to take LA supplements, the Linus Pauling Institute recommends a daily dose of 200-400 mg/day of LA for generally healthy people.

As someone who is deeply invested in maintaining a healthy lifestyle and always on the lookout for high-quality supplements, I've used several other products from Dr. Danielle and have not been disappointed. Alpha-Lipoic Acid (R-ALA) is another standout product from this company. Unlike many generic ALA supplements on the market, this one contains Alpha R Lipoic Acid (R-ALA) — the naturally occurring and more bioavailable form of lipoic acid. This means your body can absorb and utilize it more effectively, giving you better results in less time. I've personally noticed improvements in my nerve health and energy levels, and I feel a more stable sense of well-being throughout the day. I also like the company's commitment to clean, conscious ingredients. It's Non-GMO, gluten-free, vegan, and soy-free, which is perfect for someone like me with dietary sensitivities or those who prefer to avoid unnecessary additives. As someone who follows a plant-based diet, I really appreciate the veggie capsules—they’re easy to take and gentle on my stomach. I've also seen a noticeable improvement in my blood sugar stability, especially during long workdays or after meals. While I take several supplements, I believe Dr. Danielle’s Alpha-Lipoic Acid is playing a key role in maintaining my metabolic balance and overall vitality. Bottom line: If you're serious about your health and looking for a supplement that supports neuropathy, blood sugar regulation, and antioxidant protection, this is a must-try. Dr. Danielle’s reputation for clean, scientifically-backed wellness products shines through in this formula. I’ll definitely be keeping this one in my daily regimen. Highly recommend!

了解しました！ この商品の **星5・英語・短めレビュー** を作成します。 --- **★★★★★ Excellent Quality and Noticeable Results** I’ve been very impressed with this Alpha-Lipoic Acid supplement. It’s clean, vegan, and easy on the stomach. After taking it consistently, I’ve noticed improved energy and better nerve comfort. The capsules are easy to swallow, and I appreciate that it’s non-GMO and gluten-free. Highly recommend!

I am a researcher by nature so after very careful reading (from multiple sources), I determined that APA would be worth a try for neuropathic pain. Unfortunately, most ALA supplements on the market are full of fillers and additives. I was pleasantly surprised to find Dr. Danielle's APA was the most beneficial R form and free of additives, fillers, etc. The only reason for 4 stars instead of 5 is that I have not yet noted any improvement in my symptoms. Clearly, that is not the fault of the product itself. Also, several reviewers mentioned heartburn after taking the APA. I had the same experience, but found that if I took it between meals (at least 2 hours AFTER breakfast and one hour BEFORE lunch), I had NO side effects. In an effort to maintain full disclosure, I must share that the company does have an incentive program for posting a review. However, my comments are completely my own. In fact, if I had any negative experiences with either the product or the company, I would not want to take advantage of the incentive. In my case, both the customer service and the quality of the product were worth promoting...

No so much effective as shown and advertised Not recommend to my all Indians